Area tegmentalis ventralis

Area tegmentalis ventralis

Area tegmentalis in mesencephalo locata est.

Area tegmentalis ventralis (VTA) cum substantia nigra

Area tegmentalis ventralis (TA: 14.1.06.007) (abbreviatura internationalis VTA) mesencephali est grex neuronorum A10 et initium itineris mesocorticolimbici ad corticem praefrontalem. Neurotransmissor est dopaminum. Parti systematis remunerationis areae tegmentali ventrali munera cognitionis, motivationis, orgasmi sunt^[1].

Anatomia

Area tegmentalis ventralis in gregres anteriorem et posteriorem dividitur. Insunt:

Area parafasciculi retroflexi
Area parabrachialis
Nucleus parainterfascicularis
Nucleus paranigralis
Cauda areae tegmentalis ventralis (= nucleus tegmentalis rostromedialis)

Physiologia

Itinera afferentia

Receptoria et GABA (GABAA) et adrenergica α₁ (α1-AR) responsa VTA movent^[2]. Indita in aream tegmentalem ventralem per fasciculum telencephalicum medialem ab nucleis septalibus, in parte post transmissionem in nucleo praeoptico, immergunt.

Itinera efferentia

Axones in corticem praefrontalem^[3], gyrum cinguli, hippocampum, nucleum accumbentem, bulbum olfactorium, amygdalam prodeunt.

Tractus mesolimbicus

Conferatur pagina principalis: Tractus mesolimbicus.

Tractus mesolimbicus est coniunctio dopaminergica inter aream tegmentalem ventralem et nucleum accumbentem, corticem praefrontalem, nucleum caudatum, bulbum olfactorium, hippocampum, et corpus amygdaloideum.

Notae

↑ Holly E. N., Miczek K. A. (2016). "Ventral tegmental area dopamine revisited: effects of acute and repeated stress". Psychopharmacology (Berl) 233 (2): 163-86
↑ Velásquez-Martínez M. C., Vázquez-Torres R., Rojas L. V., Sanabria P., Jiménez-Rivera C. A. (2015). "Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons". Neuropharmacology 88: 110-21
↑ Puig M. V., Antzoulatos E. G., Miller E. K. (2014). "Prefrontal dopamine in associative learning and memory". Neuroscience 282: 217-29

Nexus interni

[1] Holly E. N., Miczek K. A. (2016). "Ventral tegmental area dopamine revisited: effects of acute and repeated stress". Psychopharmacology (Berl) 233 (2): 163-86

[2] Velásquez-Martínez M. C., Vázquez-Torres R., Rojas L. V., Sanabria P., Jiménez-Rivera C. A. (2015). "Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons". Neuropharmacology 88: 110-21

[3] Puig M. V., Antzoulatos E. G., Miller E. K. (2014). "Prefrontal dopamine in associative learning and memory". Neuroscience 282: 217-29

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