Receptorium acetylcholini muscarinicum M1
| Receptorium M1 | |||||
|---|---|---|---|---|---|
| Alia nomina | M1R | ||||
| Locus geni (homo) | |||||
 | |||||
| Chromosoma | 11 (humanum) | ||||
| Locus | 11q12.3 (homo) | ||||
| Fontes externae | OMIM: 118510 | ||||
Receptorium acetylcholini M1 (M1R) est receptorium muscarinium et proteino G copulatum. In hominibus genum eius in chromosomate 11 locatum est. Nomen geni est CHRM1.
Receptoria M1 imprimis in systemate nervoso centrali inveniuntur, quare ea subtypi neuronales vocitantur[1].
Multae antagonistae notae sunt, inter eas etiam medicamenta ut Olanzapinum, Quetiapinum.
Physiologia
[recensere | fontem recensere]M1 muscarinicum acetylcholini receptorium (M1 mAChR) cum proteino Gαq coniuncta sunt[2], receptorium proteino G copulatum. Stimulatum quasdam kinases ut proteini kinases C (PKC) et A (PKA), velut GPTases parvas (RAS, proteinum G parvum) incitat. Ita activatae et proteini kinases et GPTases epitonia molecularia quoque agunt.
Proteina G, proteinum Gα et subunitas q suum
[recensere | fontem recensere]
Conferatur pagina principalis: Proteinum G.Inveniuntur heterotrimerica (subunitatibus α, β, γ) proteina cum Gα superficie interna intracellulari[3]. Proteina G epitonia molecularia simplicia videri possunt: Stimulatum enim proteinum statum suum brevis temporis mutant. Dissoluta ab heterodimericis subunitatibus β et γ, subunitas α (Gαq) communiter cum phospholipasi Cβ agit[4].
Proteini kinases C (PKC) et A (PKA)
[recensere | fontem recensere]PKC sunt familia kinasum, quae proteinis positionibus aminoacidorum et serini et threonini greges phosphati dant. PKA prasentiae cyclici adenosini triphosphati (cAMP) pendet.
-
PKC serino grege HO phosphatum addit
In corpore distributio
[recensere | fontem recensere]Inveniuntur receptoria M1
- in glandulis salivariis, quamquam receptoria M3 abundiora sunt[5]
Notae
[recensere | fontem recensere]- ↑ Felder C. C., Goldsmith P. J., et al. (Iul 2018). "Current Status of Muscarinic M1 and M4 Receptors as Drug Targets for Neurodegenerative Diseases". Neuropharmacology 136: 449-58
- ↑ Chen M.-W., Zhu H., et al. (Mai 2020). "PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit". Cellular and molecular neurobiology 40 (4): 547-54
- ↑ Lyon A. M., Taylor V. G., Tesmer J. J. G. (Ian 2014). "Strike a pose: Gαq complexes at the membrane". Trends in pharmacological sciences 35 (1): 23-30
- ↑ Sánchez-Fernández G., Cabezudo S., et al. (Mai 2014). "Gαq signalling: the new and the old". Cellular signalling 26 (5): 833-48
- ↑ Proctor G. B., Carpenter G. H. (2007). "Regulation of Salivary Gland Function by Autonomic Nerves". Autonomic neuroscience: basic & clinical 133 (1): 3-18
Nexus interni
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